Description

2,3,4,6-Tetrafluoropyridine is a highly fluorinated heterocyclic compound that serves as a versatile and valuable building block in advanced chemical synthesis. Its unique structure, featuring multiple fluorine atoms on the pyridine ring, makes it a critical intermediate for introducing fluorinated motifs into target molecules, which is essential for modulating their physicochemical properties. This compound is particularly sought after by researchers and manufacturers in the pharmaceutical, agrochemical, and specialty materials sectors for developing new active ingredients and functional materials with enhanced stability, bioavailability, and performance.

Application

• Pharmaceutical Intermediate: A key synthon for the development of fluorinated drug candidates, including kinase inhibitors and central nervous system (CNS) active compounds.
• Agrochemical Synthesis: Used in the production of novel herbicides, fungicides, and pesticides where fluorination improves metabolic stability and membrane permeability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials, enhancing charge transport and thermal stability.
• Polymer & Resin Modification: Incorporated as a monomer or cross-linking agent to create fluorinated polymers with superior chemical resistance, low surface energy, and thermal properties.
• Catalyst Ligand Synthesis: Utilized to prepare fluorinated pyridine-based ligands for transition metal catalysis, influencing catalyst activity and selectivity.
• Organic Synthesis Building Block: Enables nucleophilic aromatic substitution (SNAr) reactions for the selective introduction of other functional groups onto the fluorinated ring.

Basic Information

Product Name	2,3,4,6-Tetrafluoropyridine
CAS No.	3512-13-8
Molecular Formula	C5HF4N
Molecular Weight	151.06 g/mol
Synonyms	2,3,4,6-Tetrafluoropyridine; Perfluoropyridine (not fully perfluorinated, but common alias); Tetrafluoropyridine; Pyridine, 2,3,4,6-tetrafluoro-; 2,3,4,6-Tetrafluoropyridine (mixed isomers may be implied); NSC 523803; AS-68338; 1H,3H,4H,5H-Pyridine, 2,3,4,6-tetrafluoro- (tautomeric form)
EINECS	Contact for details

Quality Control

Our 2,3,4,6-Tetrafluoropyridine is produced and handled under strict quality management protocols. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality systems are designed to meet the stringent requirements of cGMP and ISO standards for advanced chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong bases and reactive metals. Recommended storage temperature is between 2°C and 8°C (refrigerated) for long-term stability, although short-term storage at controlled room temperature (15-25°C) is acceptable. Keep container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent moisture ingress and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC)	Individual impurity ≤ 1.0%
Total Impurities	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.