Description

4-Desacetyl Vinblastine is a key vinca alkaloid derivative and a critical intermediate in the synthesis of potent anticancer agents. This compound matters for its role in producing semi-synthetic chemotherapeutic drugs, offering pharmaceutical manufacturers a reliable building block for complex molecule development. It is primarily needed by research institutions, pharmaceutical R&D departments, and fine chemical producers focused on oncology drug development and advanced chemical synthesis.

Application

• Pharmaceutical Intermediate: Primary use as a precursor in the synthesis of vinblastine sulfate and related vinca alkaloid chemotherapeutic agents.
• Oncology Drug Research: Serves as a reference standard and starting material in the development of novel microtubule-targeting anticancer drugs.
• Biochemical Research: Used in studies investigating the structure-activity relationships (SAR) of vinca alkaloids and their mechanism of action.
• Fine Chemical Synthesis: A valuable chiral building block for the preparation of complex natural product analogs and specialized chemical libraries.
• Analytical Standard: Employed as a high-purity standard for quality control (QC) and analytical method development (e.g., HPLC, LC-MS) in pharmaceutical manufacturing.

Basic Information

Product Name	4-Desacetyl Vinblastine
CAS No.	3352-69-0
Molecular Formula	C44H56N4O8
Molecular Weight	768.95 g/mol
Synonyms	Vincaleukoblastine, 4-desacetyl-; Desacetylvinblastine; 4-Desacetylvinblastine; 22-Oxovincaleukoblastine; NSC 49842; Vinblastine, 4-desacetyl-; Leurocristine intermediate; Catharanthus roseus alkaloid derivative
EINECS	Contact for details

Quality Control

Our 4-Desacetyl Vinblastine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the stringent requirements for pharmaceutical intermediate use. Certificates of Analysis (COA) detailing all specifications are available upon request, supporting compliance with cGMP and relevant pharmacopeial guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label. Keep the container in a dry, cool, and well-ventilated area. For long-term storage under inert atmosphere, please contact us for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.