Description

D-[1-18O]Glucose is a stable isotope-labeled analog of D-glucose, where the oxygen-18 atom is specifically incorporated at the C-1 position. This precise labeling makes it an indispensable tracer for studying glucose metabolism, transport, and enzymatic pathways using advanced analytical techniques like mass spectrometry and NMR. It is primarily utilized by researchers and manufacturers in the fields of pharmaceutical development, metabolic research, clinical diagnostics, and biochemical synthesis where tracking molecular fate is critical.

Application

• Metabolic Flux Analysis (MFA): Used as a stable isotopic tracer to quantify intracellular metabolic pathway rates in cell cultures, tissues, and whole organisms.
• Drug Metabolism and Pharmacokinetics (DMPK): Serves as an internal standard in LC-MS/MS and GC-MS assays for the accurate quantification of glucose and its metabolites in biological matrices.
• Enzyme Mechanism Studies: Employed to investigate the catalytic mechanisms of enzymes like hexokinase and glucose-6-phosphatase, where the fate of the C-1 oxygen is monitored.
• Diagnostic Reagent Manufacturing: Incorporated into the production of calibrated standards for clinical diagnostic kits measuring glucose metabolism disorders.
• Biochemical Research: Applied in studies of glucose transport across cell membranes, glycolysis, gluconeogenesis, and the pentose phosphate pathway.
• Nutritional Science: Used in tracer studies to understand whole-body glucose turnover, insulin resistance, and energy metabolism.

Basic Information

Item	Detail
Product Name	D-[1-18O]Glucose
CAS No.	3343-70-2
Molecular Formula	C₆H₁₂¹⁸O₆
Molecular Weight	182.15 g/mol (for ¹⁸O labeled)
Synonyms	1-¹⁸O-D-Glucose; D-Glucose-1-¹⁸O; (1-¹⁸O)-D-Glucopyranose; ¹⁸O-Labeled D-Glucose; Glucose-1-¹⁸O; Stable Isotope Labeled Glucose; D-Glucose (1-¹⁸O); [1-¹⁸O]-D-Glucose
EINECS	Contact for details

Quality Control

Every batch of D-[1-18O]Glucose is produced and analyzed under strict quality management protocols. We guarantee high chemical and isotopic purity, with comprehensive testing for identity, assay, and specific isotopic enrichment. A Certificate of Analysis (COA) is provided with each shipment, detailing results from NMR, MS, and HPLC analyses. Our quality system supports compliance with the rigorous standards required for research and in-vitro diagnostic (IVD) use.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (NMR/MS)	Conforms to structure
Isotopic Enrichment (at C-1)	≥ 95 atom % ¹⁸O
Chemical Purity (HPLC)	≥ 98.0%
Specific Optical Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.