Description

D,L-Buthionine is a synthetic amino acid derivative and a potent, competitive inhibitor of γ-glutamylcysteine synthetase. This compound is crucial for research into glutathione metabolism and oxidative stress pathways. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors for biochemical studies and as a key intermediate in specialized synthesis.

Application

• Biochemical Research: A fundamental tool for depleting intracellular glutathione levels to study oxidative stress, apoptosis, and cellular detoxification mechanisms.
• Pharmaceutical Development: Used as a reference standard and an active pharmaceutical ingredient (API) intermediate in the development of compounds targeting cancer and diseases related to oxidative damage.
• Cancer Research: Employed to sensitize tumor cells to chemotherapy and radiation therapy by inhibiting glutathione synthesis, thereby reducing cellular defense against reactive oxygen species.
• Enzyme Inhibition Studies: Serves as a specific inhibitor for γ-glutamylcysteine synthetase in enzymatic assays and metabolic pathway analysis.
• Nutritional & Metabolic Studies: Applied in research investigating the role of glutathione in liver function, neuroprotection, and immune response.

Basic Information

Product Name	D,L-Buthionine
CAS No.	3343-64-4
Molecular Formula	C8H17NO4S
Molecular Weight	223.29 g/mol
Synonyms	DL-Buthionine; Buthionine; (±)-Buthionine; Buthionine (DL-Form); NSC 326231; 2-Amino-4-(butylsulfinyl)butyric Acid; Butylhomocysteine Sulfoxide; γ-Glutamylcysteine Synthetase Inhibitor
EINECS	222-098-4

Quality Control

Our D,L-Buthionine is produced and tested under a rigorous quality management system. Each batch is analyzed to ensure it meets high-purity standards suitable for research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.