Description

2-Biphenylmagnesium Bromide is a versatile organometallic reagent, specifically a Grignard reagent, widely used in synthetic organic chemistry for the formation of carbon-carbon bonds. Its primary value lies in enabling the efficient and selective introduction of the 2-biphenyl moiety into complex molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries, facilitating the synthesis of active pharmaceutical ingredients (APIs), liquid crystals, and specialty polymers.

Application

• Pharmaceutical Intermediate Synthesis: A key building block for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and drug candidates.
• Agrochemical Manufacturing: Used in the synthesis of advanced herbicides, fungicides, and insecticides that require specific biphenyl-based structures for enhanced activity.
• Material Science & Liquid Crystals: Serves as a critical precursor in the production of organic electronic materials, liquid crystal displays (LCDs), and specialty polymers.
• Cross-Coupling Reactions: An effective reagent in palladium-catalyzed cross-coupling reactions, such as Kumada couplings, to form biaryl compounds.
• Nucleophilic Addition Reactions: Employed to add the 2-biphenyl group to various electrophiles including carbonyl compounds (aldehydes, ketones, esters) and epoxides.
• Fine Chemical & Specialty Chemical Production: Integral to the custom synthesis of dyes, pigments, and other high-value fine chemicals.

Basic Information

Product Name	2-Biphenylmagnesium Bromide
CAS No.	3315-91-1
Molecular Formula	C12H9BrMg
Molecular Weight	257.41 g/mol
Synonyms	2-Biphenylylmagnesium Bromide; (1,1'-Biphenyl-2-yl)magnesium Bromide; o-Biphenylmagnesium Bromide; 2-Phenylphenylmagnesium Bromide; Grignard Reagent 2-BiphenylMgBr; Magnesium, bromo(1,1'-biphenyl-2-yl)-; Bromo(2-biphenylyl)magnesium
EINECS	Contact for details

Quality Control

Our 2-Biphenylmagnesium Bromide is manufactured under stringent quality protocols to ensure batch-to-batch consistency and reliability for critical synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay (typically as a solution in THF or diethyl ether), concentration, and impurity profile. Our quality systems are designed to support cGMP and ISO standards for customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. This material is hygroscopic (moisture-sensitive) and must be stored under an inert atmosphere (argon or nitrogen) to prevent decomposition. For solutions, store at 2-8°C under an inert gas. Keep away from heat, sparks, open flames, and oxidizing agents. Use only in a well-ventilated area or fume hood.

Specification

Item	Specification
Appearance (Solution)	Clear, colorless to light yellow or brown
Concentration (in THF or Et2O)	0.5 M - 1.0 M (Custom concentrations available)
Assay (Titration)	≥ 95%
Identification (IR / NMR)	Conforms to structure

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.