Description

2-Hydroxy-3-Methylcholanthrene is a polycyclic aromatic hydrocarbon derivative of significant interest in biochemical and toxicological research. This compound matters as a key reference standard and metabolite in studies investigating the metabolic activation and carcinogenic mechanisms of polycyclic aromatic hydrocarbons. It is primarily needed by research institutions, pharmaceutical R&D departments, and analytical laboratories focused on environmental toxicology, cancer research, and metabolic pathway analysis.

Application

• Biochemical Research Standard: Serves as a critical analytical reference standard for metabolite identification in studies of polycyclic aromatic hydrocarbon (PAH) metabolism.
• Toxicology Studies: Used in in vitro and in vivo research to investigate the carcinogenic potential and metabolic pathways of methylcholanthrene derivatives.
• Metabolite Profiling: Employed in the development and validation of analytical methods (e.g., HPLC, LC-MS) for detecting and quantifying hydroxylated PAH metabolites in biological samples.
• Mechanistic Studies: A tool for studying cytochrome P450 enzyme activity and the formation of DNA adducts, which are central to understanding chemical carcinogenesis.
• Environmental Analysis: Acts as a model compound in research assessing the human health risks associated with exposure to complex environmental PAH mixtures.
• Pharmaceutical R&D: Used in early-stage discovery research to understand drug metabolism and potential toxicological pathways of new chemical entities with similar structures.

Basic Information

Product Name	2-Hydroxy-3-Methylcholanthrene
CAS No.	3308-64-3
Molecular Formula	C21H16O
Molecular Weight	284.35 g/mol
Synonyms	3-Methylcholanthren-2-ol; 2-Hydroxy-3-methylcholanthrene; 3-MC-2-ol; 2-Hydroxy-3-MC; 2-OH-3-Methylcholanthrene; 3-Methyl-2-hydroxycholanthrene; 2-Hydroxy-3-methyl-1,2-dihydro-3-methylcholanthrene (tautomer); Hydroxymethylcholanthrene
EINECS	Contact for details

Quality Control

Our 2-Hydroxy-3-Methylcholanthrene is produced and handled under strict quality protocols to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot undergoes comprehensive analytical characterization, including purity determination by HPLC and structural confirmation. A detailed Certificate of Analysis (COA) documenting identity, purity, and analytical methods is provided with every shipment to support your research integrity and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. This compound is light-sensitive and should be handled under appropriate conditions to prevent degradation.

Specification

Item	Specification
Appearance	Off-white to light tan powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.