Description

Urea-18O is a stable isotope-labeled analog of urea, where the oxygen atom is enriched with the non-radioactive isotope Oxygen-18. This compound is a critical tool in advanced research and analytical chemistry, enabling precise metabolic and pharmacokinetic studies. It is primarily utilized by scientists and manufacturers in the pharmaceutical, biotechnology, and environmental science sectors for tracer studies, mass spectrometry, and nuclear magnetic resonance (NMR) spectroscopy.

Application

• Metabolic Tracer Studies: Used to track nitrogen metabolism and urea cycle dynamics in biological systems.
• Mass Spectrometry (MS) Internal Standard: Serves as a quantitative reference standard in LC-MS and GC-MS analyses for accurate measurement of urea levels.
• NMR Spectroscopy: Employed as a probe in structural and mechanistic studies due to the distinct NMR signal of the 18O label.
• Pharmacokinetic Research: Facilitates the study of drug metabolism and excretion pathways in preclinical and clinical research.
• Environmental Science: Applied in studies of nitrogen cycling and pollution tracking in soil and aquatic environments.
• Isotope Dilution Analysis: A key component in highly accurate quantitative analytical methods.

Basic Information

Product Name	Urea-18O
CAS No.	3138-51-0
Molecular Formula	CH4N218O
Molecular Weight	62.05 g/mol
Synonyms	Urea-18O; [18O]Urea; Carbamide-18O; Carbonyl diamide-18O; Isotopic Urea (O-18); Urea (18O-labeled); Urea, 18O-labeled; Urea (oxygen-18O)
EINECS	Contact for details

Quality Control

Our Urea-18O is produced under stringent conditions to ensure high isotopic and chemical purity, meeting the exacting requirements of research and analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment, chemical purity, and other critical parameters. We adhere to ISO 9001 quality management principles, and specifications can be aligned with customer-specific protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms
Isotopic Enrichment (18O)	≥ 95 atom %
Chemical Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.