Description

Succinic Acid-2,3-3H is a high-purity, tritium-labeled derivative of succinic acid, a key intermediate in the citric acid cycle. This labeled compound is essential for advanced metabolic and biochemical research, providing a critical tool for tracing pathways and quantifying reaction kinetics. It is primarily required by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies engaged in isotope-based studies.

Application

• Metabolic Pathway Tracing: Used as a radiolabeled tracer in studies of the Krebs cycle (TCA cycle) and related biochemical pathways.
• Drug Metabolism & Pharmacokinetics (DMPK): Critical for investigating the absorption, distribution, metabolism, and excretion (ADME) of new pharmaceutical compounds.
• Enzyme Mechanism Studies: Employed to elucidate the mechanisms of action for enzymes like succinate dehydrogenase.
• Biomedical Research: Facilitates research into cellular respiration, mitochondrial function, and energy metabolism disorders.
• Isotope Dilution Analysis: Serves as an internal standard for the accurate quantification of succinic acid and related metabolites via mass spectrometry.
• Synthesis of Labeled Compounds: Acts as a building block for the synthesis of more complex tritium-labeled molecules for research.

Basic Information

Product Name	Succinic Acid-2,3-3H
CAS No.	3073-84-5
Molecular Formula	C4H43H2O4
Molecular Weight	~120.08 g/mol (for 3H2)
Synonyms	Butanedioic-2,3-3H2 Acid; [2,3-3H]Succinic Acid; Tritiated Succinic Acid; Amber Acid-2,3-3H2; 1,2-Ethanedicarboxylic-2,3-3H2 Acid; (2,3-3H2)Succinic Acid
EINECS	Contact for details

Quality Control

Every batch of Succinic Acid-2,3-3H is manufactured and analyzed under strict quality systems to ensure exceptional purity and specific activity. Our quality control includes rigorous testing for radiochemical purity, chemical purity, and specific activity using advanced techniques like HPLC and liquid scintillation counting. A comprehensive Certificate of Analysis (COA) detailing all test results, including radionuclidic purity, is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at recommended temperatures (typically 2-8°C or as specified on the label) in a designated, well-ventilated area for radioactive materials. Follow all local and international regulations for the storage and handling of radioactive compounds.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98% (Chemical Purity)
Radiochemical Purity	≥ 97%
Specific Activity	Contact for details (Ci/mmol)
Solvent (if supplied in solution)	Specified on COA

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.