Description

U 18666A is a potent and specific small-molecule inhibitor of cholesterol biosynthesis, widely recognized in biochemical and pharmaceutical research. Its primary value lies in its ability to selectively inhibit the enzyme 2,3-oxidosqualene cyclase, a key step in the cholesterol synthesis pathway, making it an indispensable tool for studying lipid metabolism and related diseases. This compound is essential for researchers and developers in pharmaceutical R&D, academic biochemistry, and cell biology laboratories focused on atherosclerosis, neurodegenerative disorders, and lipid storage diseases.

Application

• Biochemical Research: Used as a specific inhibitor to study the cholesterol biosynthesis pathway and its regulation in cell culture and in vitro assays.
• Pharmaceutical Development: Serves as a critical reference standard and pharmacological tool in the discovery of novel therapeutics targeting hypercholesterolemia and atherosclerosis.
• Cell Biology Studies: Employed to induce intracellular cholesterol depletion in various cell lines, facilitating research on membrane dynamics, protein trafficking, and lipid raft formation.
• Neuroscience Research: Applied in models studying Niemann-Pick Type C disease and other lysosomal storage disorders linked to cholesterol homeostasis.
• Academic & Industrial R&D: A fundamental reagent for investigating the role of cholesterol in viral entry, signal transduction, and cellular differentiation processes.

Basic Information

Product Name	U 18666A
CAS No.	3039-71-2
Molecular Formula	C₂₇H₄₅NO₂
Molecular Weight	415.66 g/mol
Synonyms	3β-(2-Diethylaminoethoxy)androst-5-en-17-one; U18666A; U-18666A; 3β-[2-(Diethylamino)ethoxy]androst-5-en-17-one; (3β)-3-[2-(Diethylamino)ethoxy]androst-5-en-17-one; 2,3-Oxidosqualene Cyclase Inhibitor; OSC Inhibitor; Cholesterol Synthesis Inhibitor
EINECS	Contact for details

Quality Control

Our U 18666A is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity verification and structural confirmation via spectroscopic methods. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting the exact specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.