Description

2-Cyanobenzenesulfonyl Fluoride is a versatile and highly reactive aromatic sulfonyl fluoride derivative, serving as a critical building block in modern synthetic chemistry. Its core value lies in its dual functionality, where the sulfonyl fluoride group acts as a powerful electrophile for sulfur(VI) fluoride exchange (SuFEx) click chemistry, and the cyano group provides a handle for further transformations. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients, creating bioconjugation probes, and synthesizing complex organic intermediates.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of sulfonamide-based drug candidates, including protease inhibitors and kinase inhibitors.
• SuFEx Click Chemistry: Essential reagent for sulfur(VI) fluoride exchange reactions, enabling the rapid and reliable construction of chemical libraries and bioconjugates.
• Agrochemical Synthesis: Building block for creating novel herbicides, fungicides, and insecticides with sulfonyl fluoride or sulfonamide moieties.
• Material Science: Used in the development of advanced polymers and functional materials with specific surface properties.
• Chemical Biology Probes: Employed in activity-based protein profiling (ABPP) to label and study enzymes in complex biological systems.
• Organic Synthesis: Versatile synthon for introducing the ortho-cyanobenzenesulfonyl group into more complex molecular architectures.

Basic Information

Product Name	2-Cyanobenzenesulfonyl Fluoride
CAS No.	395-46-0
Molecular Formula	C7H4FNO2S
Molecular Weight	185.17 g/mol
Synonyms	2-Cyanobenzenesulfonyl fluoride; o-Cyanobenzenesulfonyl fluoride; Benzenesulfonyl fluoride, 2-cyano-; 2-Cyanophenylsulfonyl fluoride; ortho-Cyanobenzenesulfonyl fluoride; 2-Fluorosulfonylbenzonitrile; o-Fluorosulfonylbenzonitrile; 395-46-0
EINECS	Contact for details

Quality Control

Our 2-Cyanobenzenesulfonyl Fluoride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the exacting standards required for research and industrial synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee full traceability and support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.