Description

2-(Trifluoromethyl)Benzyl Bromide is a versatile and highly reactive organobromide building block characterized by the presence of a benzyl bromide group and a strongly electron-withdrawing trifluoromethyl substituent. This molecular architecture makes it a critical intermediate for introducing the (trifluoromethyl)benzyl moiety into more complex structures, a modification highly sought after in advanced material and pharmaceutical research for its ability to modulate lipophilicity and metabolic stability. It is essential for synthetic chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries who require high-purity, reliable intermediates for constructing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders, inflammation, and oncology, where the trifluoromethyl group enhances drug-like properties.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the (trifluoromethyl)benzyl group contributes to biological activity and environmental persistence profiles.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized phosphine ligands, N-heterocyclic carbene (NHC) precursors, and other organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Precursor: Employed in the synthesis of monomers for specialty polymers, liquid crystals, and organic electronic materials, where the fluorine content can influence thermal stability and electronic properties.
• Chemical Biology & Proteomics: Useful as a reactive handle for bioconjugation, labeling biomolecules, or developing activity-based probes (ABPs) due to the electrophilic benzyl bromide functionality.
• Cross-Coupling Reactions: Acts as an efficient electrophilic partner in various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Negishi) to form biaryl and other complex structures.

Basic Information

Product Name	2-(Trifluoromethyl)Benzyl Bromide
CAS No.	395-44-8
Molecular Formula	C8H6BrF3
Molecular Weight	239.04 g/mol
Synonyms	α-Bromo-2-(trifluoromethyl)toluene; 2-(Trifluoromethyl)phenylmethyl Bromide; (2-(Trifluoromethyl)phenyl)methyl Bromide; 1-(Bromomethyl)-2-(trifluoromethyl)benzene; o-(Trifluoromethyl)benzyl Bromide; 2-Trifluoromethylbenzyl Bromide; Benzene, 1-(bromomethyl)-2-(trifluoromethyl)-; Bromomethyl(2-trifluoromethylphenyl)
EINECS	Contact for details

Quality Control

Every batch of 2-(Trifluoromethyl)Benzyl Bromide is manufactured and tested under a strict quality management system. We employ advanced analytical techniques including GC, HPLC, and NMR to ensure identity, purity, and consistency meet the exacting standards required for research and commercial synthesis. A comprehensive Certificate of Analysis (COA) detailing all specified parameters is provided with each shipment to guarantee traceability and compliance with your internal quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from strong acids and incompatible organic solvents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC/HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.