Description

8-Fluoroquinoline is a versatile fluorinated heterocyclic building block essential for advanced organic synthesis and pharmaceutical research. Its core value lies in the strategic introduction of a fluorine atom onto the quinoline scaffold, enabling precise modulation of biological activity, lipophilicity, and metabolic stability in target molecules. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of fluorinated quinolone antibiotics and other bioactive molecules targeting CNS disorders, oncology, and anti-infective therapies.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the fluorine atom enhances compound efficacy and environmental stability.
• Material Science Precursor: Serves as a building block for creating organic light-emitting diodes (OLEDs), liquid crystals, and other fluorinated functional materials.
• Ligand and Catalyst Development: Employed in the synthesis of novel nitrogen-containing ligands for catalysis and metal-organic frameworks (MOFs).
• Chemical Research & Development: A fundamental reagent for method development in fluorination chemistry and heterocyclic compound synthesis.
• Dye and Pigment Intermediate: Used in the synthesis of specialized fluorinated dyes and pigments with unique optical properties.

Basic Information

Product Name	8-Fluoroquinoline
CAS No.	394-68-3
Molecular Formula	C9H6FN
Molecular Weight	147.15 g/mol
Synonyms	Quinoline, 8-fluoro-; 8-Fluoro-quinoline; 8-Fluorochinolin; NSC 404083; 1-Azanaphthalene, 8-fluoro-; Fluorine substituted quinoline; 8-FQ
EINECS	206-904-8

Quality Control

Our 8-Fluoroquinoline is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and purity, GC for residual solvents, and NMR/IR for structural confirmation. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting all critical quality attributes. Our production adheres to cGMP principles where applicable, supporting our commitment to supply reliability for your critical R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Purity (HPLC, Area %)	≥99.0%
Melting Point	48 - 52 °C
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals (as Pb)	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.