Description

2-Fluoronicotinic Acid CAS NO 393-55-5 is a high-purity fluorinated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both a carboxylic acid and a fluorine substituent on the pyridine ring, makes it an invaluable intermediate for creating complex molecules with tailored properties. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries, where it is used to develop new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitors and other targeted therapies.
• Agrochemical Synthesis: Used in the research and production of modern pesticides and herbicides, where the fluorine atom can enhance bioavailability and stability.
• Ligand and Catalyst Preparation: Serves as a precursor for synthesizing specialized ligands in coordination chemistry and catalysis.
• Material Science Research: Employed in the creation of advanced organic electronic materials and metal-organic frameworks (MOFs).
• Fluorine Chemistry Studies: A valuable compound for academic and industrial research into the effects of fluorination on molecular reactivity and physical properties.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds and development of scalable synthetic routes.

Basic Information

Product Name	2-Fluoronicotinic Acid
CAS No.	393-55-5
Molecular Formula	C6H4FNO2
Molecular Weight	141.10 g/mol
Synonyms	2-Fluoropyridine-3-carboxylic Acid; 3-Carboxy-2-fluoropyridine; Nicotinic Acid, 2-fluoro-; 2-Fluoro-3-pyridinecarboxylic Acid; 2-Fluoronicotinic Acid; 2-Fluoropyridine-3-carboxylic acid; 393-55-5; 2-Fluoro-3-pyridinylcarboxylic acid
EINECS	206-889-6

Quality Control

Our 2-Fluoronicotinic Acid is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with each shipment, documenting all critical parameters. Our quality commitment ensures the material meets the stringent requirements for research and cGMP-grade synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases and oxidizing agents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Melting Point	158 - 162 °C
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.