Description

2,5-Difluorobenzotrifluoride is a versatile fluorinated aromatic building block of significant commercial importance. Its unique structure, featuring both fluorine and trifluoromethyl substituents, makes it a critical intermediate in the synthesis of advanced materials and active pharmaceutical ingredients (APIs). This compound is essential for manufacturers in the agrochemical, pharmaceutical, and specialty chemical sectors seeking to introduce specific fluorine-based properties into their final products.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in central nervous system (CNS) and anti-inflammatory therapies.
• Agrochemical Synthesis: Used in the production of advanced herbicides and pesticides, where the fluorine atoms enhance biological activity and environmental stability.
• Liquid Crystal Materials: Serves as a core component in the synthesis of fluorinated liquid crystals for high-performance displays.
• Organic Electronics: Employed as a building block for electron-transport materials and semiconductors in OLEDs and organic photovoltaics.
• Specialty Polymer Modifier: Imparts desirable properties such as chemical resistance, thermal stability, and low surface energy to high-performance polymers.
• Cross-Coupling Reactions: A valuable substrate in Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to create complex biaryl structures.

Basic Information

Product Name	2,5-Difluorobenzotrifluoride
CAS No.	393-38-4
Molecular Formula	C7H3F5
Molecular Weight	200.09 g/mol
Synonyms	1,4-Difluoro-2-(trifluoromethyl)benzene; 2,5-Difluoro-α,α,α-trifluorotoluene; 2,5-Difluoro(trifluoromethyl)benzene; 2-(Trifluoromethyl)-1,4-difluorobenzene; Benzene, 1,4-difluoro-2-(trifluoromethyl)-; α,α,α,2,5-Pentafluorotoluene; 2,5-DFBTF
EINECS	206-888-5

Quality Control

Every batch of our 2,5-Difluorobenzotrifluoride is produced and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the precise requirements for sensitive applications like pharmaceutical synthesis. A detailed Certificate of Analysis (COA), including purity assay and impurity profile by GC, is supplied with each shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from heat sources and incompatible materials. Due to its highly volatile nature, ensure containers are kept tightly sealed when not in use to prevent evaporation and concentration changes. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.1%
Related Substances (GC)	Individual impurity ≤ 0.5% Total impurities ≤ 1.5%
Density (20°C)	1.45 - 1.50 g/mL
Refractive Index (n20D)	1.410 - 1.420

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.