Description

4-Hydroxy-5-Fluoroquinoline is a high-purity fluorinated quinoline derivative, serving as a critical advanced intermediate in modern organic synthesis. Its value lies in its unique molecular scaffold, which combines a quinoline core with strategically positioned hydroxyl and fluorine substituents, enabling precise structural modifications. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of novel active ingredients and complex heterocyclic compounds.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel fluoroquinolone antibiotics and other bioactive molecules targeting bacterial infections.
• Agrochemical Research: Used in developing advanced fungicides and herbicides, where the fluorine atom enhances biological activity and environmental stability.
• Material Science Precursor: Serves as a starting material for creating functionalized organic ligands and fluorinated polymers with specialized electronic or optical properties.
• Chemical Synthesis: Employed in cross-coupling reactions and as a versatile scaffold for constructing complex heterocyclic libraries in medicinal chemistry.
• Analytical Reference Standard: Utilized as a high-purity standard in HPLC and LC-MS for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	4-Hydroxy-5-Fluoroquinoline
CAS No.	386-68-5
Molecular Formula	C9H6FNO
Molecular Weight	163.15 g/mol
Synonyms	5-Fluoro-4-hydroxyquinoline; 4-Quinolinol, 5-fluoro-; 5-Fluoroquinolin-4-ol; 5-Fluoro-4-quinolinol; 4-Hydroxy-5-fluoroquinoline; 386-68-5 (CAS Registry)
EINECS	Contact for details

Quality Control

Our 4-Hydroxy-5-Fluoroquinoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for research and industrial synthesis. Certificates of Analysis (COA) detailing all specifications are available upon request, providing full traceability and quality assurance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.