Description

2,4,6-Trimethylbenzenesulfonyl Fluoride is a specialized organosulfur compound that serves as a versatile and highly reactive sulfonylating agent. Its primary value lies in its ability to act as a key building block and protecting group reagent in complex organic synthesis, particularly for the introduction of the sulfonyl fluoride functional group. This product is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries, where it is used to create novel molecular architectures and probe biological systems.

Application

• Pharmaceutical Intermediate: A critical reagent in the synthesis of active pharmaceutical ingredients (APIs), especially for creating sulfonamide-based drugs and protease inhibitors.
• Chemical Biology Probe: Used in activity-based protein profiling (ABPP) to label and study serine hydrolases and other enzymes, aiding in drug discovery and target identification.
• Agrochemical Synthesis: Serves as a building block for developing new herbicides, fungicides, and insecticides with sulfonyl fluoride motifs.
• Polymer & Materials Science: Employed in the modification of polymer surfaces and the synthesis of specialty monomers for high-performance materials.
• Peptide Chemistry: Acts as a protecting group for amino acids during solid-phase peptide synthesis (SPPS).
• Cross-coupling Reactions: Utilized in palladium-catalyzed cross-coupling reactions to form carbon-sulfur bonds.
• Fluorination Agent: Provides a source of fluorine in specific synthetic transformations to incorporate fluoride into target molecules.
• Research & Development: A valuable tool for academic and industrial R&D laboratories exploring new synthetic methodologies and reaction pathways.

Basic Information

Product Name	2,4,6-Trimethylbenzenesulfonyl Fluoride
CAS No.	384-98-5
Molecular Formula	C9H11FO2S
Molecular Weight	202.25 g/mol
Synonyms	Mesitylenesulfonyl Fluoride; 2,4,6-Trimethylphenylsulfonyl Fluoride; MesSO2F; MsF; 2,4,6-Trimethylbenzenesulphonyl Fluoride; Mesitylsulfonyl Fluoride; 2,4,6-Trimethyl-1-benzenesulfonyl Fluoride
EINECS	206-847-5

Quality Control

Our 2,4,6-Trimethylbenzenesulfonyl Fluoride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC analysis, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality parameters. Our production adheres to cGMP principles where applicable, ensuring reliability for research and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere such as nitrogen or argon to prevent degradation. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	44 - 48 °C
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.