Description

Acetic Acid, 2,2,2-Trifluoro-, Propyl Ester is a specialized fluorinated organic ester, also known by its CAS number 383-66-4. This compound is valued for its unique combination of properties as a highly volatile and strong acid/organic solvent, making it a critical intermediate and reagent in advanced chemical synthesis. It is primarily sought by industries involved in pharmaceuticals, agrochemicals, and specialty materials where its trifluoromethyl group imparts desirable characteristics like enhanced stability and lipophilicity to target molecules.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring a trifluoroacetate or trifluoroethoxy moiety.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the fluorine atoms enhance biological activity and environmental persistence.
• Specialty Solvent & Reagent: Acts as a solvent or acylating agent in sensitive organic reactions, including esterifications and acylations, where its volatility aids in easy removal.
• Fluoropolymer & Material Science: Serves as a monomer or modifier in the development of fluorinated polymers and coatings, improving chemical resistance and surface properties.
• Liquid Crystal & Electronic Chemicals: Employed in the synthesis of fluorinated liquid crystals and electronic-grade chemicals for display and semiconductor industries.
• Analytical Chemistry: Used as a derivatization agent in gas chromatography and mass spectrometry for the analysis of complex organic mixtures.

Basic Information

Product Name	Acetic Acid, 2,2,2-Trifluoro-, Propyl Ester
CAS No.	383-66-4
Molecular Formula	C5H7F3O2
Molecular Weight	156.10 g/mol
Synonyms	Propyl Trifluoroacetate; Trifluoroacetic Acid Propyl Ester; 2,2,2-Trifluoroacetic Acid Propyl Ester; TFA Propyl Ester; n-Propyl Trifluoroacetate; Propyl 2,2,2-Trifluoroacetate; 1-Propyl Trifluoroacetate; Trifluoroacetate de propyle (French)
EINECS	206-850-5

Quality Control

Our Acetic Acid, 2,2,2-Trifluoro-, Propyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, NMR, and titration, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, assay, and impurity profiles are available upon request to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from heat sources and incompatible materials such as strong bases and oxidizing agents. Due to its highly volatile nature, ensure containers are kept tightly sealed when not in use to prevent evaporation and concentration changes. Recommended storage temperature is 2-8°C for extended stability, though short-term storage at controlled room temperature (15-25°C) is acceptable.

Specification

Item	Specification
Appearance	Clear, colorless liquid
Identification (IR)	Conforms
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.1%
Acidity (as TFA)	≤ 0.5%
Refractive Index (n20D)	1.330 - 1.335
Density (20°C)	1.18 - 1.22 g/mL
Boiling Point	~ 102 - 104 °C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.