Description

Chlorodifluoroacetic Acid Ethyl Ester is a versatile fluorinated building block essential for introducing the chlorodifluoromethyl moiety into complex molecules. This compound matters for its role in creating compounds with enhanced metabolic stability, lipophilicity, and unique electronic properties. Industries that need it include pharmaceutical R&D for drug discovery, agrochemical manufacturing for novel active ingredients, and advanced material science for specialty polymers and liquid crystals.

Application

• Pharmaceutical Intermediate: Key synthon in the development of active pharmaceutical ingredients (APIs), particularly for molecules requiring the -CF2Cl pharmacophore.
• Agrochemical Synthesis: Used in the production of modern herbicides, fungicides, and insecticides where fluorine substitution improves efficacy and environmental profile.
• Fluorinated Material Precursor: Serves as a monomer or modifier in the synthesis of specialty fluoropolymers, coatings, and liquid crystals with specific chemical resistance and optical properties.
• Organic Synthesis Reagent: Employed in nucleophilic substitution and coupling reactions to introduce the chlorodifluoroacetate group into complex organic frameworks.
• Dye and Pigment Manufacturing: Used in the synthesis of advanced fluorinated dyes and pigments for high-performance applications.

Basic Information

Product Name	Chlorodifluoroacetic Acid Ethyl Ester
CAS No.	383-62-0
Molecular Formula	C4H5ClF2O2
Molecular Weight	158.53 g/mol
Synonyms	Ethyl Chlorodifluoroacetate; Chlorodifluoroacetic Acid Ethyl Ester; Ethyl 2-Chloro-2,2-difluoroacetate; 2-Chloro-2,2-difluoroacetic Acid Ethyl Ester; CDFAE; Chlorodifluoroethyl Acetate; NSC 92440; Ethyl α-Chloro-α,α-difluoroacetate
EINECS	206-847-5

Quality Control

Our Chlorodifluoroacetic Acid Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, NMR, and titration, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from heat sources and incompatible materials such as strong bases and oxidizing agents. Recommended storage temperature is 2-8°C for long-term stability. The product is a strong acid/organic solvent; handle with appropriate personal protective equipment in a fume hood.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Density (at 20°C)	1.30 - 1.35 g/mL
Refractive Index (n20D)	1.365 - 1.375

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.