Description

4-(Trifluoromethylsulfonyl)Chlorobenzene is a high-value organofluorine and sulfone building block essential for advanced chemical synthesis. This compound is particularly valued for its ability to introduce the highly stable and electron-withdrawing triflyl (trifluoromethanesulfonyl) group into target molecules. It is a critical intermediate for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially those requiring sulfonamide or trifluoromethylsulfonyl pharmacophores for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the trifluoromethylsulfonyl group can improve efficacy and environmental profile.
• Material Science: Serves as a monomer or precursor for high-performance polymers, liquid crystals, and electronic chemicals.
• Cross-Coupling Reactions: An effective electrophile in Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to create complex biaryl structures.
• Organic Synthesis Reagent: Employed as a versatile reagent for introducing the -SO2CF3 group, a powerful electron-withdrawing moiety, into aromatic systems.
• Research & Development: A valuable tool for medicinal chemistry and process chemistry research in both academic and industrial R&D laboratories.

Basic Information

Product Name	4-(Trifluoromethylsulfonyl)Chlorobenzene
CAS No.	383-11-9
Molecular Formula	C7H4ClF3O2S
Molecular Weight	244.62 g/mol
Synonyms	1-Chloro-4-(trifluoromethylsulfonyl)benzene; p-Chlorophenyl trifluoromethyl sulfone; 4-Chlorophenyl trifluoromethyl sulfone; (4-Chlorophenyl)(trifluoromethyl)sulfone; Trifluoromethanesulfonyl chloride benzene derivative; p-Triflylchlorobenzene; 4-Triflylchlorobenzene; α,α,α-Trifluoro-4-chlorobenzenemethanesulfonate
EINECS	Contact for details

Quality Control

Our 4-(Trifluoromethylsulfonyl)Chlorobenzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, assay, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.