Description

2-Thiophenesulfonyl Fluoride is a high-purity, reactive organosulfur building block characterized by its sulfonyl fluoride functional group. This compound is valued for its role as a key intermediate in the synthesis of more complex molecules, particularly in pharmaceutical and agrochemical research. It is primarily sought after by R&D chemists and process development scientists working in medicinal chemistry, where it is used to introduce the sulfonyl moiety or as a precursor for click chemistry and SuFEx (Sulfur Fluoride Exchange) applications. Its reliable quality and stability are critical for ensuring reproducible results in sensitive synthetic pathways.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing thiophene or sulfonamide scaffolds.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging its reactive fluoride for structural diversification.
• SuFEx Click Chemistry: Serves as a reliable electrophilic partner in Sulfur(VI) Fluoride Exchange reactions, a powerful tool for modular conjugation and bioconjugation in chemical biology and materials science.
• Material Science Research: Employed in the development of advanced polymers, ligands, and functional materials where the thiophene-sulfonyl group imparts specific electronic or binding properties.
• Chemical Biology Probes: Utilized to create covalent inhibitors or activity-based probes for studying enzyme function and protein labeling.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity specialty fluorides.

Basic Information

Product Name	2-Thiophenesulfonyl Fluoride
CAS No.	382-99-0
Molecular Formula	C4H3FO2S2
Molecular Weight	166.19 g/mol
Synonyms	Thiophene-2-sulfonyl fluoride; 2-Thienylsulfonyl fluoride; 2-Thiophenesulfonylfluoride; 2-Thiophenesulphonyl fluoride; Thiophene-2-sulfonic acid fluoride; 2-Fluorosulfonylthiophene; 2-Thienylsulfonic acid fluoride
EINECS	Contact for details

Quality Control

Our 2-Thiophenesulfonyl Fluoride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and purity, NMR for structural confirmation, and Karl Fischer titration for moisture content. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes. We adhere to cGMP principles where applicable to support our clients' regulatory requirements in pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.