Description

1,3-Difluorobenzene is a versatile fluorinated aromatic building block essential for advanced organic synthesis. Its unique substitution pattern makes it a critical intermediate for creating complex molecules with tailored properties. This compound is primarily utilized by R&D chemists and process engineers in the pharmaceutical, agrochemical, and specialty materials industries to develop new active ingredients and high-performance polymers.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring a meta-substituted difluorobenzene moiety.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, where the fluorine atoms enhance biological activity and stability.
• Liquid Crystal & OLED Materials: Serves as a core building block for fluorine-containing compounds used in electronic display technologies and organic light-emitting diodes.
• Polymer & Resin Modification: Incorporated into polymer chains to improve chemical resistance, thermal stability, and surface properties of high-performance plastics and coatings.
• Organic Synthesis Reagent: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution to introduce fluorinated phenyl groups.
• Research & Development: A valuable tool for medicinal chemistry and material science research in academic and industrial laboratories.

Basic Information

Product Name	1,3-Difluorobenzene
CAS No.	372-18-9
Molecular Formula	C6H4F2
Molecular Weight	114.09 g/mol
Synonyms	m-Difluorobenzene; 1,3-Difluorobenzol; Benzene, 1,3-difluoro-; meta-Difluorobenzene; 3-Fluorophenyl fluoride; F-Benzene,1,3-di
EINECS	206-748-2

Quality Control

Our 1,3-Difluorobenzene is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications. We support cGMP and ISO 9001 standards for reliable supply to regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from heat, sparks, and open flame. Due to its highly volatile nature and classification as a fluoride/strong alkali, keep containers tightly sealed and separate from incompatible materials. Recommended storage temperature is 2-25°C.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.1%
Density (at 20°C)	1.15 - 1.18 g/mL
Boiling Point	82-84°C
Refractive Index (n20D)	1.440 - 1.444

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.