Description

4-Iodotoluene Difluoride is a high-purity fluorinated aromatic building block essential for advanced organic synthesis. This compound is valued for its unique reactivity, where the iodine and fluorine substituents enable selective cross-coupling and functionalization reactions. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries to create novel molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for fluorinated drug candidates targeting CNS disorders and oncology.
• Agrochemical Synthesis: Used in the development of novel herbicides and pesticides, where the fluorine atoms enhance biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated liquid crystals and organic light-emitting diode (OLED) materials, improving electronic properties and thermal stability.
• Cross-Coupling Reactions: The iodine moiety acts as an excellent handle for palladium-catalyzed reactions like Suzuki, Sonogashira, and Negishi couplings to construct complex biaryl systems.
• Fluorination Reagent Precursor: Can be used to prepare reagents for nucleophilic or electrophilic fluorination in late-stage synthesis.
• Polymer Modification: Incorporated into specialty polymers to impart unique solubility, surface energy, and chemical resistance properties.

Basic Information

Product Name	4-Iodotoluene Difluoride
CAS No.	371-11-9
Molecular Formula	C7H5F2I
Molecular Weight	253.92 g/mol
Synonyms	1-Iodo-2,4-difluorobenzene; 2,4-Difluoroiodobenzene; 2,4-Difluoro-1-iodobenzene; 4-Iodo-1,3-difluorobenzene; 1,3-Difluoro-4-iodobenzene; (2,4-Difluorophenyl)iodide; 371-11-9; Iodobenzene, 2,4-difluoro-
EINECS	206-740-9

Quality Control

Our 4-Iodotoluene Difluoride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high chemical purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to guarantee consistency and traceability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider using amber glass containers or wrapping clear containers in light-blocking material.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.