Description

4-Methoxybenzenesulfonyl Fluoride is a versatile and highly reactive organosulfur compound, serving as a crucial building block in advanced organic synthesis. Its primary value lies in its role as a selective sulfonylating agent, particularly for the introduction of the methoxybenzenesulfonyl (Mbs) protecting group in peptide chemistry and pharmaceutical intermediate manufacturing. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries who require precise and efficient synthetic methodologies.

Application

• Pharmaceutical Intermediate Synthesis: Key reagent for introducing sulfonamide and sulfonate ester functionalities in active pharmaceutical ingredient (API) development.
• Peptide Chemistry: Used as a protecting group reagent for amines (particularly the methoxybenzenesulfonyl or Mbs group), offering stability under various reaction conditions.
• Agrochemical Manufacturing: Building block for synthesizing sulfonylurea-based herbicides and other crop protection agents.
• Material Science: Monomer or precursor for creating specialized polymers and functional materials with specific surface properties.
• Chemical Biology & Proteomics: Employed in activity-based protein profiling (ABPP) and as a probe for studying serine hydrolases due to its sulfonyl fluoride warhead.
• Cross-Coupling Reactions: Serves as an electrophilic coupling partner in palladium-catalyzed reactions for constructing complex biaryl structures.

Basic Information

Product Name	4-Methoxybenzenesulfonyl Fluoride
CAS No.	368-91-2
Molecular Formula	C7H7FO3S
Molecular Weight	190.19 g/mol
Synonyms	p-Methoxybenzenesulfonyl Fluoride; 4-Methoxybenzene-1-sulfonyl Fluoride; Anisole-4-sulfonyl Fluoride; Mbs-F; MBS-F; 4-Methoxybenzenesulfonylfluoride; 4-Methoxy-phenylsulfonyl Fluoride; (4-Methoxyphenyl)sulfonyl Fluoride
EINECS	206-710-5

Quality Control

Every batch of our 4-Methoxybenzenesulfonyl Fluoride is produced and tested under a strict quality management system. We guarantee high purity and consistency to meet the rigorous demands of research and commercial-scale synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment, ensuring full traceability and compliance with your internal specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong bases and moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	40 - 44 °C
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.