Description

Benzenesulfonylfluoride, 4-Hydroxy- is a versatile aromatic sulfonyl fluoride derivative, recognized for its unique reactivity as a selective and irreversible protease inhibitor. This compound is a critical building block and biochemical tool, valued for its ability to covalently modify serine residues in active sites. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and agrochemical sectors for drug discovery, proteomics research, and the synthesis of more complex bioactive molecules.

Application

• Protease Inhibition Research: Serves as a key active site-directed inhibitor for studying serine proteases in biochemical and pharmacological assays.
• Pharmaceutical Intermediate: Used in the synthesis of more complex sulfonamide-based drug candidates targeting various diseases.
• Chemical Biology & Proteomics: Acts as a reactive handle in activity-based protein profiling (ABPP) to identify and characterize enzyme function in complex biological systems.
• Agrochemical Synthesis: Employed as a precursor in the development of novel pesticides and herbicides, leveraging its sulfonyl fluoride moiety.
• Material Science: Investigated for surface modification and polymer functionalization due to its specific reactivity under mild conditions.

Basic Information

Product Name	Benzenesulfonylfluoride, 4-Hydroxy-
CAS No.	368-87-6
Molecular Formula	C6H5FO3S
Molecular Weight	176.17 g/mol
Synonyms	4-Hydroxybenzenesulfonyl fluoride; p-Hydroxybenzenesulfonyl fluoride; Phenol, 4-(fluorosulfonyl)-; 4-Fluorosulfonylphenol; 4-Hydroxybenzene-1-sulfonyl fluoride; 4-HBSF; p-HBSF; 368-87-6
EINECS	206-719-6

Quality Control

Our Benzenesulfonylfluoride, 4-Hydroxy- is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and FTIR, to ensure high purity and consistent performance for research and synthesis applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to guarantee reliable and reproducible results for your critical work.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed and under an inert atmosphere for long-term storage to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	92 - 96 °C
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.