Description

4-Fluorobenzenesulfonyl Fluoride is a versatile and highly reactive organosulfur compound that serves as a critical building block in advanced chemical synthesis. Its dual sulfonyl fluoride functional group makes it an invaluable reagent for introducing the 4-fluorobenzenesulfonyl moiety, a key structural motif in modern pharmaceuticals and agrochemicals. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries who require a reliable, high-purity intermediate for sulfonylation and cross-coupling reactions.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of sulfonamide-based drugs, including protease inhibitors and kinase inhibitors.
• Agrochemical Synthesis: Used in the production of novel herbicides and fungicides that incorporate fluorinated sulfonyl groups for enhanced activity and stability.
• Chemical Biology & Proteomics: Acts as a reactive handle in activity-based protein profiling (ABPP) and the development of covalent enzyme inhibitors.
• Material Science: Serves as a monomer or cross-linking agent in the synthesis of specialty polymers and functionalized surfaces.
• Suzuki-Miyaura Cross-Coupling: A valuable electrophilic coupling partner in palladium-catalyzed reactions to create biaryl systems.
• Fluorination Chemistry: Provides a source of the fluorosulfonyl group for further fluorination reactions in medicinal chemistry.

Basic Information

Product Name	4-Fluorobenzenesulfonyl Fluoride
CAS No.	368-85-4
Molecular Formula	C6H4F2O2S
Molecular Weight	178.16 g/mol
Synonyms	p-Fluorobenzenesulfonyl Fluoride; 4-Fluorophenylsulfonyl Fluoride; Benzenesulfonyl Fluoride, 4-fluoro-; 1-Fluoro-4-(fluorosulfonyl)benzene; 4-Fluoro-1-sulfonylfluorobenzene; p-Fluorophenylsulfonyl Fluoride; 4-FBSF
EINECS	206-716-5

Quality Control

Our 4-Fluorobenzenesulfonyl Fluoride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high chemical purity and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We adhere to cGMP principles where applicable to support our customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent hydrolysis. Keep away from strong bases and incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.