Description

3-Amino-4-Chlorobenzenesulfonyl Fluoride is a versatile and reactive aromatic sulfonyl fluoride derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both an amino group and a highly reactive sulfonyl fluoride moiety, makes it an invaluable precursor for constructing complex molecules. This compound is essential for research and development chemists and process engineers in the pharmaceutical, agrochemical, and specialty chemical industries, where it is used to create novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of sulfonamide-based drugs, including protease inhibitors, diuretics, and antibacterial agents.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and insecticides that incorporate sulfonylurea or sulfonamide scaffolds.
• Chemical Biology & Proteomics: Serves as a reactive handle in activity-based protein profiling (ABPP) and the development of covalent enzyme inhibitors due to the sulfonyl fluoride group's selectivity for certain amino acids.
• Material Science: Precursor for modifying polymer surfaces and creating functionalized materials with specific chemical properties.
• Dye and Pigment Manufacturing: Intermediate in the synthesis of specialized azo dyes and pigments requiring chlorinated and sulfonated aromatic structures.
• Cross-coupling Reactions: The amino and chloro groups make it a suitable substrate for various palladium-catalyzed coupling reactions to create more complex biaryl structures.

Basic Information

Product Name	3-Amino-4-Chlorobenzenesulfonyl Fluoride
CAS No.	368-72-9
Molecular Formula	C6H5ClFNO2S
Molecular Weight	209.63 g/mol
Synonyms	4-Chloro-3-aminobenzenesulfonyl Fluoride; 3-Amino-4-chlorobenzenesulfonyl Fluoride; 4-Chloro-3-aminophenylsulfonyl Fluoride; Benzenesulfonyl fluoride, 3-amino-4-chloro-; 3-Amino-4-chlorophenylsulfonyl fluoride; 4-Chloro-m-aminobenzenesulfonyl Fluoride; 3-Amino-4-chlorobenzene-1-sulfonyl fluoride
EINECS	Contact for details

Quality Control

Our 3-Amino-4-Chlorobenzenesulfonyl Fluoride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and industrial synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to guarantee traceability and consistency for your critical processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.