Description

2-(Trifluoromethyl)Pyridine is a versatile fluorinated heterocyclic building block essential for advanced organic synthesis. Its unique trifluoromethyl group adjacent to the pyridine nitrogen imparts significant electronic and lipophilic properties, making it a critical intermediate for developing high-value specialty chemicals. This compound is primarily sought after by R&D and production teams in the pharmaceutical, agrochemical, and material science industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), particularly in antiviral, anticancer, and central nervous system (CNS) drug candidates.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis for asymmetric synthesis.
• Material Science: Building block for synthesizing fluorinated liquid crystals, organic semiconductors, and polymers with tailored electronic and surface properties.
• Chemical Research: A valuable reagent in academic and industrial R&D for exploring new fluorination methodologies and structure-activity relationships (SAR).
• Dye & Pigment Industry: Intermediate for producing specialty fluorinated dyes and pigments with improved lightfastness and solubility.

Basic Information

Product Name	2-(Trifluoromethyl)Pyridine
CAS No.	368-48-9
Molecular Formula	C6H4F3N
Molecular Weight	147.10 g/mol
Synonyms	2-(Trifluoromethyl)pyridine; α,α,α-Trifluoro-2-picoline; 2-Picoline, trifluoromethyl-; 2-Trifluoromethylpyridine; 2-TFM-Pyridine; Pyridine, 2-(trifluoromethyl)-; 2-CF3-Pyridine; NSC 221986
EINECS	206-698-4

Quality Control

Our 2-(Trifluoromethyl)Pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC/HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Due to its highly volatile nature, keep away from heat, sparks, and open flame. Ensure the container is kept upright to prevent leakage. Incompatible with strong bases and fluorinating agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20/D)	1.440 - 1.444
Density (g/mL at 25°C)	1.280 - 1.320

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.