Description

Benzenesulfonyl Fluoride is a versatile organosulfur reagent featuring a reactive sulfonyl fluoride group. This compound is a critical building block in chemical synthesis, valued for its role as a selective and stable electrophile in SuFEx (Sulfur(VI) Fluoride Exchange) click chemistry. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries developing novel small molecules, polymers, and bioconjugates.

Application

• Pharmaceutical Intermediate: Key reagent in the synthesis of sulfonamide-based drug candidates and for the selective modification of proteins and peptides.
• SuFEx Click Chemistry: A fundamental electrophile for robust, reliable sulfur(VI) fluoride exchange reactions to create stable linkages under mild conditions.
• Chemical Biology Probe: Used to develop activity-based probes (ABPs) for profiling enzyme activity and function in complex biological systems.
• Polymer & Materials Science: Serves as a monomer or cross-linking agent for creating advanced polymeric materials with specific functional properties.
• Agrochemical Synthesis: Intermediate in the production of herbicides, fungicides, and other crop protection agents containing sulfonyl groups.
• Ligand & Catalyst Development: Building block for constructing novel ligands and organocatalysts used in asymmetric synthesis.

Basic Information

Product Name	Benzenesulfonyl Fluoride
CAS No.	368-43-4
Molecular Formula	C6H5FO2S
Molecular Weight	160.17 g/mol
Synonyms	Benzenesulfonyl fluoride; Phenylsulfonyl fluoride; Benzene sulfonyl fluoride; Benzenesulfonic acid fluoride; BSF; Phenylsulfonylfluoride; Fluorosulfonylbenzene; EINECS 206-709-3
EINECS	206-709-3

Quality Control

Our Benzenesulfonyl Fluoride is produced under stringent quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications. We support cGMP manufacturing for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to prevent hydrolysis. Keep away from strong bases and strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Density	~1.33 g/cm³ at 20°C
Refractive Index	~1.479 at 20°C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.