Description

2-Bromo-5-Nitrobenzotrifluoride is a versatile halogenated aromatic building block of significant importance in advanced organic synthesis. Its unique structure, featuring bromine, nitro, and trifluoromethyl substituents, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring halogenated aromatic cores or trifluoromethyl groups to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, where the nitro and bromo groups serve as handles for further functionalization.
• Liquid Crystal & OLED Materials: Serves as a building block for electron-deficient aromatic units in the production of specialty electronic materials for displays and lighting.
• Cross-Coupling Reactions: The bromine atom is an excellent site for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira) to form biaryl structures.
• Dye & Pigment Intermediate: Utilized in the synthesis of complex, high-performance dyes and pigments, contributing to color fastness and specific spectral properties.
• Polymer Chemistry: Acts as a monomer or functionalization agent for creating specialty polymers with specific thermal, optical, or chemical resistance properties.

Basic Information

Product Name	2-Bromo-5-Nitrobenzotrifluoride
CAS No.	367-67-9
Molecular Formula	C7H3BrF3NO2
Molecular Weight	269.99 g/mol
Synonyms	1-Bromo-2-nitro-4-(trifluoromethyl)benzene; 2-Bromo-α,α,α-trifluoro-5-nitrotoluene; Benzene, 1-bromo-2-nitro-4-(trifluoromethyl)-; 5-Nitro-2-bromobenzotrifluoride; 2-Bromo-5-nitro-α,α,α-trifluorotoluene; 4-Trifluoromethyl-2-bromonitrobenzene; 2-Bromo-5-nitrobenzylidene trifluoride
EINECS	Contact for details

Quality Control

Our 2-Bromo-5-Nitrobenzotrifluoride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistent performance. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Off-white to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	48 - 52 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.