Description

1,2-Difluorobenzene is a versatile fluorinated aromatic compound, valued for its role as a key building block in advanced chemical synthesis. Its unique structure, featuring two adjacent fluorine atoms on the benzene ring, makes it a critical intermediate for introducing fluorinated motifs into target molecules. This product is essential for R&D and production in the pharmaceutical, agrochemical, and specialty materials sectors, where precise fluorination is required to modulate biological activity, stability, and physical properties. CAS No. 367-11-3.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds requiring fluorinated aromatic systems to enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and pesticides, where the difluorobenzene moiety contributes to product efficacy and environmental profile.
• Liquid Crystal & OLED Materials: Acts as a building block for fluorinated components in electronic display materials, improving dielectric anisotropy and overall performance.
• Polymer & Resin Modification: Employed to introduce fluorine into polymer chains, enhancing chemical resistance, thermal stability, and surface properties of specialty plastics and coatings.
• Organic Synthesis Reagent: A valuable reagent in cross-coupling reactions (e.g., Suzuki, Negishi) and nucleophilic aromatic substitution for constructing complex fluorinated organic molecules.
• Solvent & Reaction Medium: Utilized as a specialty solvent in certain fluorination reactions and for dissolving fluorinated compounds due to its specific polarity and stability.

Basic Information

Product Name	1,2-Difluorobenzene
CAS No.	367-11-3
Molecular Formula	C6H4F2
Molecular Weight	114.09 g/mol
Synonyms	o-Difluorobenzene; 1,2-Difluorobenzol; Benzene, 1,2-difluoro-; ortho-Difluorobenzene; o-Difluorobenzol; 1,2-Difluoro-Benzene; 2,3-Difluorobenzene (incorrect but common alternate numbering); FBE (abbreviation in some contexts)
EINECS	206-692-5

Quality Control

Our 1,2-Difluorobenzene is produced and tested under a strict quality management system. Each batch is analyzed to ensure it meets high-purity standards suitable for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing parameters such as assay, identity, and impurity profiles. We support compliance with relevant global regulatory frameworks, including REACH.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from heat sources and incompatible materials such as strong acids and strong bases. Due to its highly volatile nature, ensure containers are securely sealed. Recommended storage temperature is between 15°C and 25°C.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to standard
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.1%
Related Substances (GC)	Individual impurity ≤ 0.5%
Density (at 20°C)	1.15 - 1.18 g/mL
Boiling Point	91 - 93 °C
Refractive Index (n20D)	1.440 - 1.444

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.