Description

Ay 9944 is a high-purity, synthetic organic compound identified by CAS NO 366-93-8. This specialized chemical is valued for its role as a potent and selective inhibitor of cholesterol biosynthesis, specifically targeting the enzyme δ7-sterol reductase (DHCR7). It is an essential research tool for scientists and manufacturers in the pharmaceutical and life sciences sectors, enabling critical studies in lipid metabolism, neurodegenerative disease models, and the development of therapeutic agents.

Application

• Biochemical Research: Used as a key inhibitor to study the cholesterol biosynthesis pathway, specifically to induce the accumulation of 7-dehydrocholesterol (7-DHC) in cellular and animal models.
• Pharmaceutical Development: Serves as a reference standard and active pharmaceutical ingredient (API) intermediate in the research and development of drugs targeting lipid disorders.
• Disease Modeling: Critical for creating in vitro and in vivo models of Smith-Lemli-Opitz Syndrome (SLOS), a genetic disorder of cholesterol metabolism, to study disease mechanisms and potential treatments.
• Neuroscience Studies: Employed to investigate the role of cholesterol and its precursors in neuronal development, synaptic function, and neurodegenerative processes.
• Cell Biology: Utilized to modulate membrane lipid composition and raft dynamics in various cell lines to understand their impact on signaling and transport.
• Reference Standard: Supplied as a certified reference material for quality control and analytical method development in regulatory and academic laboratories.

Basic Information

Product Name	Ay 9944
CAS No.	366-93-8
Molecular Formula	C₂₆H₂₈Cl₂N₂O
Molecular Weight	455.42 g/mol
Synonyms	AY-9944; trans-1,4-Bis(2-chlorobenzylaminomethyl)cyclohexane dihydrochloride; AY 9944 dihydrochloride; AY9944; DHCR7 Inhibitor; δ7-Sterol Reductase Inhibitor; Cholesterol Biosynthesis Inhibitor
EINECS	Contact for details

Quality Control

Our Ay 9944 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and residual solvent analysis. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided to ensure traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.