Description

5-Bromo-2-Iodobenzotrifluoride is a versatile halogenated aromatic building block of significant importance in advanced organic synthesis. Its unique structure, featuring both bromine and iodine substituents on a trifluoromethylated benzene ring, makes it a critical intermediate for constructing complex molecules. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in cross-coupling reactions and material science.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to introduce complex aryl groups.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, leveraging the reactivity of its halogen atoms for structural diversification.
• Material Science Research: Serves as a monomer or building block for creating specialized polymers, liquid crystals, and organic electronic materials due to the electron-withdrawing trifluoromethyl group.
• Chemical Biology & Diagnostics: Employed in the synthesis of molecular probes, tags, and contrast agents where the iodine atom can be utilized for radiolabeling or further functionalization.
• Organic Ligand Preparation: Useful for synthesizing sophisticated ligands for catalysis, where the halogenated aromatic core can be further modified to tune steric and electronic properties.

Basic Information

Product Name	5-Bromo-2-Iodobenzotrifluoride
CAS No.	364-12-5
Molecular Formula	C7H3BrF3I
Molecular Weight	350.90 g/mol
Synonyms	2-Iodo-5-bromobenzotrifluoride; 1-Bromo-4-iodo-2-(trifluoromethyl)benzene; 5-Bromo-2-iodo-α,α,α-trifluorotoluene; 5-Bromo-2-iodobenzotrifluoride; 2-Iodo-5-bromo-α,α,α-trifluorotoluene; Benzene, 1-bromo-4-iodo-2-(trifluoromethyl)-; (5-Bromo-2-iodophenyl)trifluoromethane
EINECS	Contact for details

Quality Control

Our 5-Bromo-2-Iodobenzotrifluoride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and elemental analysis, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.