Description

Fluorocitrate CAS NO 357-89-1 is a potent and specific metabolic inhibitor that acts as a competitive antagonist of aconitase in the citric acid cycle. This compound is of significant value in biochemical and pharmacological research for its ability to induce selective chemical lesions, mimicking aspects of certain neurodegenerative conditions. It is primarily utilized by research institutions, pharmaceutical R&D departments, and diagnostic manufacturers focused on neuroscience, cellular metabolism, and enzyme inhibition studies.

Application

• Biochemical Research: Used as a specific inhibitor of the enzyme aconitase to study the citric acid cycle (Krebs cycle) and cellular energy metabolism.
• Neuropharmacology Studies: Employed to create experimental models of impaired cellular metabolism, particularly in glial cells, for researching neurodegenerative pathways.
• Enzyme Kinetics & Mechanism: Serves as a critical tool for investigating enzyme inhibition mechanisms, substrate specificity, and active site characterization.
• Metabolic Pathway Analysis: Applied in cell biology to block specific metabolic steps, allowing researchers to map and understand flux through biochemical networks.
• Toxicology & Safety Assessment: Used in studies to understand the effects of metabolic poisons and to evaluate potential protective agents or antidotes.
• Diagnostic Development: May be utilized in the development of assays and kits designed to measure aconitase activity or diagnose related metabolic disorders.

Basic Information

Product Name	Fluorocitrate
CAS No.	357-89-1
Molecular Formula	C6H7FO7
Molecular Weight	210.12 g/mol
Synonyms	2-Fluorocitric acid; (1R,2S)-1-Fluoro-2-hydroxy-1,2,3-propanetricarboxylic acid; 2-Fluoro-2-hydroxy-1,2,3-propanetricarboxylic acid; Fluorocitric acid; DL-Fluorocitrate; (±)-Fluorocitric acid; NSC 71964; Aconitase inhibitor
EINECS	Contact for details

Quality Control

Our Fluorocitrate is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical testing, including identification by spectroscopic methods and purity assessment by chromatography. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming specifications for identity, purity, and related substances.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be kept under dry conditions. For long-term storage, consider desiccant use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 3.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.