Description

1,1,2,2,2-Pentafluoroethanesulfonyl Fluoride is a highly reactive fluorinated sulfonyl fluoride derivative, serving as a critical building block for advanced chemical synthesis. Its primary value lies in its ability to introduce the versatile pentafluoroethylsulfonyl (PES) group into target molecules, enabling the development of materials with enhanced properties. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty polymer industries seeking to create novel compounds with improved stability, lipophilicity, or biological activity.

Application

• Pharmaceutical Intermediate: Key reagent for synthesizing active pharmaceutical ingredients (APIs), particularly in the development of sulfonamide-based drugs and protease inhibitors.
• Agrochemical Synthesis: Used to create novel herbicides, fungicides, and insecticides with the pentafluoroethylsulfonyl moiety for improved efficacy and environmental profile.
• Polymer & Material Science: Serves as a monomer or modifier for producing high-performance fluoropolymers, surfactants, and ion-exchange resins with exceptional chemical and thermal resistance.
• Ligand & Catalyst Development: Employed in organometallic chemistry to create specialized ligands that enhance catalytic activity and selectivity in cross-coupling reactions.
• Battery Electrolyte Additive: Investigated for use in lithium-ion battery electrolytes to improve interfacial stability and cycle life.
• Click Chemistry Reagent: Acts as a substrate in SuFEx (Sulfur(VI) Fluoride Exchange) click chemistry, enabling rapid and reliable bioconjugation and polymer functionalization.

Basic Information

Product Name	1,1,2,2,2-Pentafluoroethanesulfonyl Fluoride
CAS No.	354-87-0
Molecular Formula	C2HF6O2S
Molecular Weight	200.08 g/mol
Synonyms	Pentafluoroethanesulfonyl Fluoride; 1,1,2,2,2-Pentafluoroethanesulfonyl Fluoride; Perfluoroethanesulfonyl Fluoride; Pentafluoroethylsulfonyl Fluoride; Ethanesulfonyl Fluoride, 1,1,2,2,2-pentafluoro-; PES-F; FESF; NSC 88284
EINECS	Contact for details

Quality Control

Our 1,1,2,2,2-Pentafluoroethanesulfonyl Fluoride is manufactured under stringent quality management systems. Every batch undergoes comprehensive analytical testing, including GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment to support your quality assurance and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis and degradation. Keep away from strong bases and sources of ignition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.