Description

Trifluoroacetamidine is a high-value organofluorine building block characterized by its reactive amidine group flanked by a strongly electron-withdrawing trifluoromethyl moiety. This unique structure makes it a critical intermediate for synthesizing complex heterocycles and fine chemicals, particularly in advanced pharmaceutical and agrochemical research. It is essential for medicinal chemists and process development scientists working on novel active ingredients, where its incorporation can significantly alter the metabolic stability and binding affinity of target molecules.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of nitrogen-containing heterocycles such as pyrimidines, triazines, and imidazoles, which are core structures in many drug candidates.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and environmental persistence.
• Ligand and Catalyst Preparation: Serves as a starting material for creating specialized ligands and organocatalysts used in asymmetric synthesis and transition metal catalysis.
• Material Science Research: Employed in the development of novel fluorinated polymers and advanced materials with specific thermal or chemical resistance properties.
• Chemical Biology Probes: Utilized to create labeled compounds and molecular probes for studying enzyme mechanisms and biological pathways.

Basic Information

Product Name	Trifluoroacetamidine
CAS No.	354-37-0
Molecular Formula	C3H3F3N2
Molecular Weight	124.06 g/mol
Synonyms	2,2,2-Trifluoroacetamidine; Trifluoroethanimidamide; TFAA; N-(Trifluoroacetyl)formamidine; 2,2,2-Trifluoroethanimidamide; 354-37-0; Trifluoroacetic acid amidine
EINECS	206-562-9

Quality Control

Our Trifluoroacetamidine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including chromatographic purity assays and identity confirmation, to ensure it meets the stringent requirements for research and development applications. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting key parameters such as assay purity and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after each use to prevent moisture absorption, which can compromise product integrity. Keep away from incompatible materials such as strong acids and oxidizers.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.