Description

4-(Trifluoromethylthio)Toluene is a high-value fluorinated aromatic building block characterized by the presence of both a trifluoromethylthio (-SCF₃) group and a methyl substituent. This unique structure makes it a critical intermediate for introducing lipophilicity and metabolic stability into advanced molecules. It is primarily sought after by R&D and production teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and inflammatory diseases.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the -SCF₃ group enhances biological activity and environmental persistence.
• Material Science: Serves as a monomer or modifier in the production of specialty polymers and liquid crystals with unique optical and electronic properties.
• Organic Synthesis: A versatile reagent for introducing the pharmacologically privileged trifluoromethylthioether moiety into complex organic molecules via cross-coupling reactions.
• Chemical Research: Employed in academic and industrial R&D for exploring new reaction pathways and creating compound libraries for high-throughput screening.

Basic Information

Product Name	4-(Trifluoromethylthio)Toluene
CAS No.	352-68-1
Molecular Formula	C₈H₇F₃S
Molecular Weight	192.20 g/mol
Synonyms	p-(Trifluoromethylthio)toluene; 1-Methyl-4-(trifluoromethylthio)benzene; 4-Methylphenyl trifluoromethyl sulfide; α,α,α-Trifluoro-p-tolyl mercaptan; p-Tolyl trifluoromethyl thioether; 4-(Trifluoromethylsulfanyl)toluene; 4-Methyl-1-(trifluoromethylthio)benzene
EINECS	206-524-8

Quality Control

Our 4-(Trifluoromethylthio)Toluene is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including GC, HPLC, and NMR, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications. We support cGMP and ISO standards for production and can accommodate custom purity requirements for critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids and oxidizing agents. Recommended storage temperature is between 15°C and 25°C. Keep container tightly sealed when not in use to prevent moisture absorption and volatilization.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC)	Total impurities ≤ 2.0%
Density (at 20°C)	1.30 - 1.35 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.