Description

1-Chloro-4-Fluorobenzene is a versatile halogenated aromatic building block of significant importance in advanced organic synthesis. Its value lies in the synergistic reactivity of the chlorine and fluorine substituents, enabling selective functionalization for the creation of complex molecular architectures. This compound is essential for research and production in the pharmaceutical, agrochemical, and specialty chemical industries, where it serves as a key precursor for active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A critical starting material for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of fluorinated drugs which often exhibit enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the manufacture of herbicides, fungicides, and insecticides, where the introduction of fluorine atoms can improve pesticidal activity and environmental profile.
• Liquid Crystal & Electronic Chemicals: Serves as a precursor in the production of fluorinated liquid crystals for displays and as a building block for specialty polymers and electronic materials.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions like Suzuki, Negishi, and Buchwald-Hartwig aminations, allowing for efficient carbon-carbon and carbon-heteroatom bond formation.
• Organic Synthesis & Research: Employed in laboratories and pilot plants for developing novel synthetic methodologies and creating fluorinated analogs of bioactive compounds for structure-activity relationship (SAR) studies.
• Dye & Pigment Manufacturing: Acts as an intermediate in the synthesis of specialized dyes and pigments that require halogenated aromatic cores for specific color and stability properties.

Basic Information

Product Name	1-Chloro-4-Fluorobenzene
CAS No.	352-33-0
Molecular Formula	C6H4ClF
Molecular Weight	130.55 g/mol
Synonyms	4-Chlorofluorobenzene; p-Chlorofluorobenzene; 1-Fluoro-4-chlorobenzene; 4-Fluorochlorobenzene; p-Fluorochlorobenzene; Fluorochlorobenzene (mixed isomers may be implied); Benzene, 1-chloro-4-fluoro-
EINECS	206-524-0

Quality Control

Our 1-Chloro-4-Fluorobenzene is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to guarantee compliance with your specific research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids and bases. Recommended storage temperature is between 15°C and 25°C. Keep container tightly sealed when not in use to prevent moisture absorption and volatilization.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.5%
Water Content (KF)	≤ 0.1%
Related Substances (GC)	Total impurities ≤ 1.5%
Density (at 20°C)	1.250 - 1.270 g/mL
Refractive Index (n20D)	1.495 - 1.505

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.