Description

Benzene, 1-Chloro-4-(Fluoromethyl)- is a specialized halogenated aromatic compound, identified by CAS NO 352-12-5. This chemical serves as a versatile and critical building block in advanced organic synthesis, valued for its unique reactivity profile. It is essential for research and development chemists and process engineers in the pharmaceutical and agrochemical industries who require high-purity intermediates for complex molecule construction.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing fluorinated motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, where the introduction of fluorine and chlorine atoms can improve efficacy and environmental profile.
• Liquid Crystal & OLED Material Precursor: Serves as a foundational unit for creating fluorinated aromatic cores used in electronic display technologies.
• Organic Synthesis Building Block: Employed in cross-coupling reactions (e.g., Suzuki, Heck) and nucleophilic substitution reactions to construct complex polyfunctional aromatic systems.
• Polymer Modification Agent: Can be used to introduce functional groups into polymer chains to alter physical properties like solubility, thermal stability, and chemical resistance.
• Research & Development: A valuable reagent for medicinal chemistry and material science research exploring new fluorinated compounds.

Basic Information

Product Name	Benzene, 1-Chloro-4-(Fluoromethyl)-
CAS No.	352-12-5
Molecular Formula	C7H6ClF
Molecular Weight	144.57 g/mol
Synonyms	4-(Chloromethyl)fluorobenzene; 1-Chloro-4-(fluoromethyl)benzene; p-(Chloromethyl)fluorobenzene; 4-Fluorobenzyl chloride; α-Chloro-4-fluorotoluene; (4-Fluorophenyl)methyl chloride; p-Fluorobenzyl chloride
EINECS	206-522-0

Quality Control

Every batch of Benzene, 1-Chloro-4-(Fluoromethyl)- is produced and analyzed under strict quality management protocols to ensure consistency and reliability for your synthetic processes. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as purity, identity, and impurity profiles. Our quality systems are designed to meet the stringent requirements of cGMP and ISO standards where applicable, supporting your regulatory compliance needs from development to commercial scale.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from incompatible materials such as strong bases and oxidizing agents. Due to its nature as a strong acid/organic solvent and highly volatile compound, it is recommended to store at controlled room temperature (15-25°C) under an inert atmosphere if specified for high-purity grades. Keep container tightly sealed when not in use to prevent moisture ingress and evaporation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC)	Individual impurity ≤ 1.0%
Density	1.18 - 1.22 g/cm³ @ 20°C
Refractive Index	1.485 - 1.495 @ 20°C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.