Description

5-Fluoro-Nicotinoyl Chloride is a versatile and highly reactive fluorinated aromatic acid chloride derivative. This compound serves as a critical building block in advanced organic synthesis, enabling the efficient introduction of the 5-fluoronicotinoyl moiety into target molecules. It is primarily utilized by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and material science sectors for developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other targeted therapies.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides with enhanced efficacy and selectivity.
• Ligand and Probe Development: Essential for constructing fluorinated ligands for biochemical assays and diagnostic imaging probes.
• Material Science: Building block for fluorinated polymers and advanced organic electronic materials to modify solubility and electronic properties.
• Custom Synthesis & Contract Manufacturing: Employed in research-scale and pilot-scale production for custom chemical entities.
• Academic & Industrial R&D: Fundamental reagent in medicinal chemistry and process development laboratories for structure-activity relationship (SAR) studies.

Basic Information

Item	Details
Product Name	5-Fluoro-Nicotinoyl Chloride
CAS No.	350-04-9
Molecular Formula	C6H3ClFNO
Molecular Weight	159.55 g/mol
Synonyms	5-Fluoronicotinoyl chloride; 5-Fluoropyridine-3-carbonyl chloride; 3-Pyridinecarbonyl chloride, 5-fluoro-; Nicotinoyl chloride, 5-fluoro-; 5-Fluoro-3-pyridinecarbonyl chloride; 5-Fluoronicotinic acid chloride
EINECS	Contact for details

Quality Control

Our 5-Fluoro-Nicotinoyl Chloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality system is designed to meet the rigorous standards required for pharmaceutical and advanced chemical research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.