Description

4-Nitrobenzenesulfonyl Fluoride is a versatile and highly reactive sulfonylating agent, primarily valued for its role as a key building block in organic synthesis. Its unique structure, featuring both a strong electron-withdrawing nitro group and a reactive sulfonyl fluoride moiety, makes it indispensable for introducing the 4-nitrobenzenesulfonyl (Nosyl) protecting group. This compound is essential for research chemists and process development scientists working in pharmaceutical, agrochemical, and advanced material sectors, where precise molecular modification is required.

Application

• Pharmaceutical Intermediate: A critical reagent in the synthesis of active pharmaceutical ingredients (APIs), particularly for introducing sulfonamide functionalities and as a Nosyl (Ns) protecting group for amines.
• Peptide Chemistry: Used in solid-phase peptide synthesis (SPPS) as a protecting group for amino acids, offering stability during synthesis and selective deprotection.
• Agrochemical Synthesis: Serves as a building block for creating novel herbicides, fungicides, and insecticides that contain sulfonyl-based active components.
• Chemical Biology & Proteomics: Employed in activity-based protein profiling (ABPP) and the development of covalent enzyme inhibitors due to its reactivity with serine hydrolases and other nucleophilic residues.
• Polymer & Material Science: Acts as a monomer or cross-linking agent in the production of specialty polymers, including sulfonated polymers for ion-exchange membranes.
• Dye & Pigment Manufacturing: Utilized as an intermediate in the synthesis of sulfonated azo dyes and other colorants.

Basic Information

Product Name	4-Nitrobenzenesulfonyl Fluoride
CAS No.	349-96-2
Molecular Formula	C6H4FNO4S
Molecular Weight	205.16 g/mol
Synonyms	p-Nitrobenzenesulfonyl Fluoride; 4-Nitrobenzenesulfonyl Fluoride; Nosyl Fluoride; Ns-F; 4-NO2-Bs-F; Benzenesulfonyl fluoride, 4-nitro-; 4-Nitrobenzene-1-sulfonyl fluoride; 1-Fluorosulfonyl-4-nitrobenzene
EINECS	206-500-6

Quality Control

Our 4-Nitrobenzenesulfonyl Fluoride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and purity, and is supplied with a detailed Certificate of Analysis (COA). We adhere to relevant industry standards and can support requirements for cGMP, ISO, or other regulatory frameworks as needed for your application.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to air, moisture, or light should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	92 - 96 °C
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.