Description

5-Chloro-2-(Trifluoromethyl)Pyridine is a versatile and high-value fluorinated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, combining a halogenated pyridine core with a trifluoromethyl group, makes it an essential intermediate for creating compounds with enhanced biological activity and physicochemical properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: Key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in antiviral, anticancer, and central nervous system (CNS) drug candidates.
• Agrochemical Synthesis: Used in the manufacture of advanced pesticides, herbicides, and fungicides, where the trifluoromethyl group improves lipophilicity and metabolic stability.
• Material Science: Serves as a precursor for functionalized ligands and monomers used in specialty polymers and advanced materials.
• Chemical Research: A valuable reagent in academic and industrial R&D for exploring new fluorination chemistry and heterocyclic compound libraries.
• Liquid Crystal & Electronic Chemicals: Potential building block for fluorine-containing liquid crystal molecules and electronic chemical materials.

Basic Information

Product Name	5-Chloro-2-(Trifluoromethyl)Pyridine
CAS No.	349-94-0
Molecular Formula	C6H3ClF3N
Molecular Weight	181.54 g/mol
Synonyms	2-(Trifluoromethyl)-5-chloropyridine; 5-Chloro-2-trifluoromethylpyridine; 5-Chloro-α,α,α-trifluoro-2-picoline; 2-Picoline, 5-chloro-α,α,α-trifluoro-; 349-94-0; 5-Chloro-2-(trifluoromethyl)pyridine; 5-Chloro-2-(trifluoromethyl)azine
EINECS	Contact for details

Quality Control

Our 5-Chloro-2-(Trifluoromethyl)Pyridine is produced under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality commitment ensures the material meets the stringent requirements for use in GMP-oriented pharmaceutical synthesis and other critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. The container must be kept tightly sealed due to potential moisture sensitivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.