Description

4-Fluorobenzenesulfonyl Chloride is a key organosulfur intermediate characterized by its reactive sulfonyl chloride group and aromatic fluorine substituent. This compound is essential for introducing the 4-fluorobenzenesulfonyl moiety into target molecules, enabling the synthesis of advanced chemical entities. It is primarily sought after by research and development laboratories and production facilities in the pharmaceutical, agrochemical, and specialty chemical industries for creating sulfonamides and other functional derivatives.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for creating sulfonamide-based drugs with potential antibacterial, diuretic, or anticancer properties.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and pesticides, where the fluorobenzenesulfonyl group can enhance biological activity and stability.
• Material Science Research: Serves as a monomer or modifying agent in the production of specialized polymers, resins, and advanced materials with tailored properties.
• Dye and Pigment Manufacturing: Acts as an intermediate in the synthesis of sulfonated dyes and organic pigments.
• Chemical Biology & Proteomics: Utilized as a reagent for protein labeling, activity-based profiling, and the development of chemical probes due to its electrophilic reactivity.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis projects and scale-up production under cGMP or ISO standards for client-specific molecules.

Basic Information

Product Name	4-Fluorobenzenesulfonyl Chloride
CAS No.	349-88-2
Molecular Formula	C6H4ClFO2S
Molecular Weight	194.61 g/mol
Synonyms	p-Fluorobenzenesulfonyl chloride; 4-Fluorophenylsulfonyl chloride; Benzenesulfonyl chloride, 4-fluoro-; 1-Fluoro-4-(chlorosulfonyl)benzene; 4-Fluoro-1-sulfonyl chloride benzene; p-Fluorophenylsulfonyl chloride; 4-FBSCl; 4-Fluorobenzene-1-sulfonyl chloride
EINECS	206-498-5

Quality Control

Our 4-Fluorobenzenesulfonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports applications requiring material traceability and compliance with relevant regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and reacts with water and strong bases; ensure containers are kept tightly sealed under an inert atmosphere such as nitrogen or argon for long-term storage. Keep away from heat, open flames, and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	32 - 36 °C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.