Description

3-Nitrobenzenesulphonyl Fluoride 97 is a high-purity, reactive aromatic sulfonyl fluoride derivative. This compound serves as a versatile and critical building block in advanced organic synthesis, particularly for introducing the sulfonyl fluoride functional group. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries who require a reliable, high-quality reagent for click chemistry, proteomics, and the development of covalent inhibitors.

Application

• Pharmaceutical Intermediate: Key synthon for the development of covalent drug candidates and enzyme inhibitors targeting serine hydrolases.
• Chemical Biology & Proteomics: Used in activity-based protein profiling (ABPP) as a reactive probe for labeling and identifying active sites in enzymes.
• Agrochemical Synthesis: Building block for creating novel sulfonamide-based herbicides, fungicides, and pesticides with enhanced efficacy.
• Polymer & Material Science: Monomer or cross-linking agent for synthesizing specialty polymers with specific surface functionalities.
• Sulfur(VI) Fluoride Exchange (SuFEx) Chemistry: A premier click chemistry reagent for constructing stable S-VI linkages under mild conditions.
• Organic Synthesis Reagent: Used in nucleophilic substitution reactions to introduce the 3-nitrobenzenesulfonyl moiety into complex molecules.

Basic Information

Product Name	3-Nitrobenzenesulphonyl Fluoride 97
CAS No.	349-78-0
Molecular Formula	C6H4FNO4S
Molecular Weight	205.16 g/mol
Synonyms	3-Nitrobenzenesulfonyl Fluoride; m-Nitrobenzenesulfonyl Fluoride; 3-Nitrobenzene-1-sulfonyl Fluoride; Benzenesulfonyl Fluoride, 3-nitro-; NSC 403121; 1-Fluorosulfonyl-3-nitrobenzene; m-Nitrobenzene Sulfonyl Fluoride; 3-Nitrobenzenesulfonic Acid Fluoride
EINECS	206-500-9

Quality Control

Our 3-Nitrobenzenesulphonyl Fluoride 97 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee compliance with your research and production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	Off-white to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.