Description

4-Acetamido-3-Fluorobenzene-1-Sulfonyl Chloride is a high-purity, reactive sulfonyl chloride derivative, serving as a critical building block in advanced organic synthesis. Its value lies in its dual functional groups, enabling the introduction of both a sulfonamide linkage and a protected aniline moiety into target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing active pharmaceutical ingredients (APIs) and specialty fine chemicals.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel sulfonamide-based drug candidates, including enzyme inhibitors and receptor antagonists.
• Agrochemical Synthesis: Used in the development of advanced herbicides and fungicides where the sulfonamide group confers specific biological activity.
• Chemical Biology & Proteomics: Acts as a reactive handle for labeling proteins or synthesizing activity-based probes (ABPs) due to its electrophilic sulfonyl chloride group.
• Material Science Research: Employed in the creation of specialized polymers and functional materials requiring sulfonamide linkages for enhanced properties.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects requiring precise, multi-step functionalization of aromatic systems.

Basic Information

Product Name	4-Acetamido-3-Fluorobenzene-1-Sulfonyl Chloride
CAS No.	349-71-3
Molecular Formula	C8H7ClFNO3S
Molecular Weight	251.66 g/mol
Synonyms	N-[5-(Chlorosulfonyl)-2-fluorophenyl]acetamide; 2-Fluoro-5-acetamidobenzenesulfonyl chloride; 4-Acetamido-3-fluorobenzenesulfonyl chloride; 5-Acetamido-2-fluorobenzenesulfonyl chloride; 2-Fluoro-5-acetylaminobenzenesulfonyl chloride; 349-71-3; 4-Acetylamino-3-fluorobenzenesulfonyl chloride
EINECS	Contact for details

Quality Control

Our 4-Acetamido-3-Fluorobenzene-1-Sulfonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via FT-IR and NMR, to ensure it meets the high standards required for research and industrial synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Assay	97.0 - 103.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.