Description

Trifluoromethanesulfonyl Fluoride is a versatile and highly reactive fluorinating and sulfonylating agent, serving as a key building block in advanced chemical synthesis. Its primary commercial value lies in its ability to efficiently introduce the triflyl (Tf) group, enabling the creation of complex molecules with enhanced properties. This compound is essential for R&D and production in the pharmaceutical, agrochemical, and specialty materials industries, where precise fluorination and robust synthetic intermediates are required.

Application

• Pharmaceutical Intermediate: Critical for the synthesis of active pharmaceutical ingredients (APIs), particularly in creating sulfonamide derivatives and fluorinated drug candidates.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, where the trifluoromethanesulfonyl group can improve biological activity and stability.
• Polymer & Material Science: Acts as a monomer or modifying agent for producing high-performance polymers, including ion-exchange membranes and specialty fluoropolymers.
• Organic Synthesis Reagent: A powerful reagent for introducing the triflyl group in fine chemical synthesis, facilitating reactions like trifluoromethanesulfonylation.
• Lithium Battery Electrolyte Additive: Investigated for use in electrolyte formulations to enhance the stability and performance of lithium-ion batteries.
• Catalyst & Ligand Preparation: Employed in the synthesis of metal-organic catalysts and specialized ligands used in asymmetric catalysis.

Basic Information

Product Name	Trifluoromethanesulfonyl Fluoride
CAS No.	335-05-7
Molecular Formula	CF4O2S
Molecular Weight	152.06 g/mol
Synonyms	Triflyl Fluoride; Trifluoromethylsulfonyl Fluoride; Perfluoromethanesulfonyl Fluoride; TfF; Trifluoromethanesulfonic Acid Fluoride; Fluorosulfonyl Trifluoromethane; CF3SO2F
EINECS	206-392-8

Quality Control

Our Trifluoromethanesulfonyl Fluoride is manufactured under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications. We adhere to cGMP principles where applicable to support our customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Due to its highly volatile and hygroscopic nature, store in a cool, dry, well-ventilated area, preferably under an inert atmosphere such as nitrogen or argon. Recommended storage temperature is 2-8°C. Keep away from strong acids, bases, and moisture.

Specification

Item	Specification
Appearance	Colorless liquid to gas
Identification (IR)	Conforms
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.1%
Acidity (as CF3SO3H)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.