Description

1-(2-Chloroethyl)-4-Fluorobenzene is a versatile halogenated aromatic building block of significant importance in advanced organic synthesis. Its bifunctional structure, featuring both a reactive chloroethyl side chain and a fluorinated aromatic ring, makes it a critical intermediate for constructing complex molecular architectures. This compound is primarily utilized by research institutions and manufacturers in the pharmaceutical and agrochemical industries for the development of active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds requiring a fluorobenzyl or phenethylamine scaffold.
• Agrochemical Synthesis: Used in the research and production of herbicides, fungicides, and insecticides, where the fluorine atom can enhance biological activity and metabolic stability.
• Liquid Crystal & Electronic Chemicals: Serves as a building block for fluorinated liquid crystal materials and other specialty electronic chemicals.
• Organic Synthesis & Research: A valuable reagent for introducing the 2-chloroethyl-4-fluorophenyl moiety in medicinal chemistry and material science research.
• Cross-Coupling Reactions: Acts as a substrate in various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to create more complex biaryl systems.

Basic Information

Product Name	1-(2-Chloroethyl)-4-Fluorobenzene
CAS No.	332-43-4
Molecular Formula	C8H8ClF
Molecular Weight	158.60 g/mol
Synonyms	2-(4-Fluorophenyl)ethyl chloride; 4-Fluorophenethyl chloride; 1-Chloro-2-(4-fluorophenyl)ethane; (4-Fluorophenyl)ethyl chloride; p-Fluorophenethyl chloride; 4-Fluorobenzeneethanamine, N-chloro derivative (related); β-Chloro-4-fluorotoluene (common misnomer)
EINECS	206-366-6

Quality Control

Our 1-(2-Chloroethyl)-4-Fluorobenzene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and impurity profiles against our stringent specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC)	Individual impurity ≤ 1.0%
Total Impurities	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.