Description

2,5-Bis(Trifluoromethyl)Chlorobenzene is a high-value, multi-functional fluorinated aromatic building block essential for advanced chemical synthesis. Its unique structure, featuring two electron-withdrawing trifluoromethyl groups and a reactive chlorine substituent, makes it a critical intermediate for creating complex molecules with enhanced properties. This compound is primarily sought after by R&D and production teams in the pharmaceutical, agrochemical, and specialty materials industries for developing new active ingredients and performance chemicals.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) and metabolic diseases.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the trifluoromethyl groups improve biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials, enhancing dielectric anisotropy and thermal stability.
• Polymer & Resin Modifier: Incorporated into specialty polymers to impart oil, solvent, and chemical resistance, as well as to lower surface energy.
• Catalyst Ligand Precursor: Utilized in the preparation of sophisticated ligand systems for catalysis in asymmetric synthesis and cross-coupling reactions.
• Organic Synthesis Reagent: Acts as a versatile reagent in nucleophilic aromatic substitution and cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to introduce fluorinated aryl groups.

Basic Information

Product Name	2,5-Bis(Trifluoromethyl)Chlorobenzene
CAS No.	328-91-6
Molecular Formula	C8H3ClF6
Molecular Weight	248.55 g/mol
Synonyms	1-Chloro-2,5-bis(trifluoromethyl)benzene; 2,5-Bis(trifluoromethyl)phenyl chloride; α,α,α,α',α',α'-Hexafluoro-2,5-dimethylchlorobenzene; 2,5-Di(trifluoromethyl)chlorobenzene; Benzene, 1-chloro-2,5-bis(trifluoromethyl)-; 2,5-Bis(trifluoromethyl)-1-chlorobenzene; 2,5-BTFMCB
EINECS	206-337-5

Quality Control

Our 2,5-Bis(Trifluoromethyl)Chlorobenzene is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistent performance. We provide full traceability and detailed Certificates of Analysis (COA) with each shipment, confirming compliance with agreed specifications. Our quality commitment supports your regulatory needs for R&D and cGMP production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and sources of ignition. Due to its fluoride/strong alkali chemical property, ensure it is stored separately from incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Density (at 20°C)	~1.55 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.