Description

2,4-Bis(Trifluoromethyl)Chlorobenzene is a high-value fluorinated aromatic building block characterized by its electron-deficient benzene ring and reactive chlorine substituent. This compound is essential for synthesizing advanced materials and active pharmaceutical ingredients (APIs) where the introduction of trifluoromethyl groups is required to modulate lipophilicity, metabolic stability, and electronic properties. It is primarily sought after by R&D chemists and process engineers in the pharmaceutical, agrochemical, and specialty materials industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system (CNS) disorders, oncology, and anti-infectives, where the CF3 groups enhance bioavailability and binding affinity.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and insecticides, where the fluorinated aromatic core contributes to improved weather resistance, pesticidal activity, and environmental persistence.
• Ligand & Catalyst Development: Serves as a starting material for creating sophisticated ligands in transition metal catalysis, enabling challenging cross-coupling and C-H activation reactions in fine chemical production.
• Organic Electronic Materials: Employed in the research and development of organic light-emitting diodes (OLEDs), semiconductors, and liquid crystal displays (LCDs) due to its ability to fine-tune electron transport properties.
• Polymer & Resin Modifier: Incorporated into high-performance polymers, coatings, and resins to impart enhanced chemical resistance, thermal stability, and low surface energy characteristics.
• Custom Synthesis & Contract Manufacturing: A critical raw material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences market.

Basic Information

Product Name	2,4-Bis(Trifluoromethyl)Chlorobenzene
CAS No.	327-76-4
Molecular Formula	C8H3ClF6
Molecular Weight	248.55 g/mol
Synonyms	1-Chloro-2,4-bis(trifluoromethyl)benzene; 2,4-Bis(trifluoromethyl)phenyl chloride; α,α,α,α',α',α'-Hexafluoro-2,4-xyllyl chloride; 2,4-Di(trifluoromethyl)chlorobenzene; Benzene, 1-chloro-2,4-bis(trifluoromethyl)-; 2,4-Bis(trifluoromethyl)-1-chlorobenzene; 2,4-(CF3)2C6H3Cl
EINECS	Contact for details

Quality Control

Our 2,4-Bis(Trifluoromethyl)Chlorobenzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports compliance with REACH and other global regulatory frameworks for industrial chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases and incompatible organic solvents. The container should be kept tightly sealed to prevent moisture ingress and potential decomposition.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.1%
Related Substances (GC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.