Description

1,2,4,5-Tetrafluorobenzene is a versatile fluorinated aromatic building block essential for advanced chemical synthesis. Its unique substitution pattern makes it a critical intermediate for creating complex molecules with tailored electronic and physical properties. This compound is primarily sought after by R&D chemists and process engineers in the pharmaceutical, agrochemical, and specialty materials industries for applications ranging from active pharmaceutical ingredient (API) development to liquid crystal and polymer production.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those requiring fluorinated aromatic cores for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and pesticides, where the fluorine atoms contribute to improved efficacy and environmental profile.
• Liquid Crystal Materials: Acts as a fundamental building block for fluorinated liquid crystals used in high-performance displays (LCDs) due to its ability to modify dielectric anisotropy and viscosity.
• Polymer & Specialty Materials: Incorporated into high-performance polymers, such as polyarylates and engineering plastics, to enhance thermal stability, chemical resistance, and optical properties.
• Organic Electronics: Utilized in the synthesis of charge-transport materials, semiconductors, and electroactive compounds for OLEDs and organic photovoltaics.
• Chemical Research & Development: A valuable reagent for exploring new fluorination methodologies and constructing complex, multi-fluorinated aromatic systems in academic and industrial labs.

Basic Information

Product Name	1,2,4,5-Tetrafluorobenzene
CAS No.	327-54-8
Molecular Formula	C6H2F4
Molecular Weight	150.07 g/mol
Synonyms	Benzene, 1,2,4,5-tetrafluoro-; Tetrafluorobenzene (mixed isomers); p-Difluorobenzene, tetrafluoro-; 1,2,4,5-Tetrafluorobenzol; NSC 9235; UNII-8I5QDG0H8M; Perfluorobenzene (historical, incorrect but common); F4-Benzene (abbreviation)
EINECS	206-332-1

Quality Control

Our 1,2,4,5-Tetrafluorobenzene is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including GC, HPLC, NMR, and Karl Fischer titration, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications. We support cGMP and ISO 9001 standards for pharmaceutical and industrial applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated place away from heat sources and incompatible materials such as strong acids and organic solvents. Due to its highly volatile nature, ensure containers are kept tightly sealed when not in use. Recommended storage temperature is 2-8°C for long-term stability, though short-term storage at controlled room temperature (15-25°C) is acceptable.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.1%
Related Substances (GC)	Total impurities ≤ 2.0%
Density (at 20°C)	1.500 - 1.550 g/mL
Refractive Index (n20D)	1.420 - 1.430

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.