Description

2-Naphthalenesulfonyl Fluoride is a versatile sulfonyl fluoride derivative, a key intermediate in organic synthesis and medicinal chemistry. Its primary value lies in its reactivity as a sulfonylating agent, particularly useful for introducing the sulfonyl group under mild conditions. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries developing new active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Crucial for the synthesis of sulfonamide-based drug candidates, including enzyme inhibitors and receptor antagonists.
• Chemical Biology Probe: Used in activity-based protein profiling (ABPP) to label and study serine hydrolases and other enzymes.
• Agrochemical Synthesis: Serves as a building block for creating novel herbicides, fungicides, and plant growth regulators with sulfonyl moieties.
• Polymer & Material Science: Acts as a monomer or modifier in the production of specialty polymers, resins, and advanced materials.
• Cross-coupling Reactions: Employed in palladium-catalyzed coupling reactions (e.g., Suzuki, Sonogashira) to create complex biaryl structures.
• Fluorination Reagent: Utilized as a source of fluorine in specific synthetic transformations to prepare fluorinated compounds.

Basic Information

Product Name	2-Naphthalenesulfonyl Fluoride
CAS No.	325-12-2
Molecular Formula	C₁₀H₇FO₂S
Molecular Weight	210.22 g/mol
Synonyms	2-Naphthalenesulfonyl fluoride; β-Naphthalenesulfonyl fluoride; 2-Naphthylsulfonyl fluoride; NSC 404080; Naphthalene-2-sulfonyl fluoride; 2-Sulfonylfluoronaphthalene; B-Naphthalenesulfonyl Fluoride
EINECS	206-300-7

Quality Control

Our 2-Naphthalenesulfonyl Fluoride is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	92 - 96 °C
Loss on Drying	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.